MOTS-c — Research Profile
MOTS-c is a 16–amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Research has explored its role in mitochondrial-nuclear communication, metabolic signaling, and AMPK pathway activa...
Overview
MOTS-c is a 16–amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Research has explored its role in mitochondrial-nuclear communication, metabolic signaling, and AMPK pathway activation in cellular and animal models.
History
MOTS-c was identified in 2015 as one of the first characterized mitochondrial-derived peptides (MDPs), opening a new field of peptide research focused on signals originating from the mitochondrial genome.
MOTS-c Structure
- CAS #: 1627580-64-6
- Molecular Formula: C₇₈H₁₂₄N₂₂O₂₂S
- Molecular Weight: 1791.05 g/mol
- PubChem ID: 117567929
Research Findings
Research on MOTS-c has examined its modulation of AMPK signaling, glucose uptake, and metabolic homeostasis. Animal models have studied effects on metabolic flexibility and exercise capacity correlates.
Key Areas of Research
- Mitochondrial: MDP signaling, mitochondrial-nuclear axis
- Metabolic: AMPK pathway, glucose uptake
- Cellular: oxidative phosphorylation dynamics
- Longevity: age-correlated expression studies
As one of the earliest characterized mitochondrial-derived peptides, MOTS-c is an active area of metabolic and aging-related research.
References
- [1]Lee C. et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. (2015).
- [2]Reynolds J. C. et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline. (2021).
All references link to the corresponding PubMed record. Citations maintained for transparency — Viora articles are sourced from the published research literature.