PT-141 — Research Profile
PT-141 (Bremelanotide) is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Research has explored its action on melanocort...
Overview
PT-141 (Bremelanotide) is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Research has explored its action on melanocortin receptor signaling and downstream behavioral and physiological correlates.
History
PT-141 emerged from melanocortin receptor research in the 2000s, derived from earlier tanning peptide investigations. Its differential central nervous system activity led to a distinct line of research focused on neurological signaling.
Bremelanotide (PT-141) Structure
- CAS #: 189691-06-3
- Molecular Formula: C₅₀H₆₈N₁₄O₁₀
- Molecular Weight: 1025.18 g/mol
- PubChem ID: 9941379
Research Findings
Bremelanotide has been studied in melanocortin receptor binding assays and animal behavioral models. Clinical research has examined its action via the MC4R pathway.
Key Areas of Research
- Melanocortin: MC1R/MC3R/MC4R receptor binding
- Central: hypothalamic signaling
- Behavioral: animal model studies
Melanocortin receptor research remains active, with PT-141 a frequently used pharmacological tool.
References
- [1]King S. H. et al. Melanocortin receptor agonists in research. (2017).
- [2]Pfaus J. G. et al. The pharmacology of melanocortin receptor activation in CNS. (2007).
All references link to the corresponding PubMed record. Citations maintained for transparency — Viora articles are sourced from the published research literature.